Title :
Time-constant-based CMOS readout circuit for DNA detection
Author :
Teo, T.H. ; Oung, K.-L. ; Chen, X.T. ; Gao, Z.Q. ; Fan, Y. ; Yeoh, W.G.
Author_Institution :
Inst. of Microelectron., Singapore
Abstract :
An RC-to-time constant interface circuit was implemented in 0.18 mum CMOS to characterise the conductive polymer labelled deoxyribonucleic acid (DNA) hybridisation activity on nano-sensor micro-arrays. Measured results show that sub-picomolar DNA (0.1-10 pM) are able to be differentiated with respect to their electrical parameters of 1-23 GOmega resistances parallel with 2.8 down to 0.1 nF capacitances.
Keywords :
CMOS integrated circuits; DNA; capacitance; nanoelectronics; readout electronics; DNA detection; conductive polymer labelled deoxyribonucleic acid hybridisation; electrical parameters; nano-sensor micro-arrays; readout circuit-to-time constant interface circuit; resistances parallel; sub-picomolar DNA; time-constant-based CMOS readout circuit;
Journal_Title :
Electronics Letters
DOI :
10.1049/el:20082875
