Title :
Applying silicon micromachining to cellular metabolism: measuring the rate of acidification induced in the extracellular environment
Author :
Bousse, Luc ; Parce, Wallace
Author_Institution :
Molecular Devices Corp., Menlo Park, CA, USA
Abstract :
Describes how a microphysiometer works and shows how silicon micromachining can be used to provide a multichannel capability. The authors consider extracellular acidification, metabolic rate detection, LAPS pH sensors, wells for the capture of nonadherent cells, and a multichannel flow-through microphysiometer chip.<>
Keywords :
biosensors; cellular biophysics; pH measurement; LAPS pH sensors; cellular metabolism; extracellular environment; induced acidification rate measurement; metabolic rate detection; multichannel flow-through microphysiometer chip; nonadherent cells capturing wells; silicon micromachining; Biochemistry; Biosensors; Cells (biology); Extracellular; Mechanical sensors; Micromachining; Semiconductor device measurement; Shape measurement; Silicon; Sugar;
Journal_Title :
Engineering in Medicine and Biology Magazine, IEEE
