• DocumentCode
    11099
  • Title

    Autonomous Unobtrusive Detection of Mild Cognitive Impairment in Older Adults

  • Author

    Akl, Ahmad ; Taati, Babak ; Mihailidis, Alex

  • Author_Institution
    Inst. of Biomater. & Biomed. Eng., Univ. of Toronto, Toronto, ON, Canada
  • Volume
    62
  • Issue
    5
  • fYear
    2015
  • fDate
    May-15
  • Firstpage
    1383
  • Lastpage
    1394
  • Abstract
    The current diagnosis process of dementia is resulting in a high percentage of cases with delayed detection. To address this problem, in this paper, we explore the feasibility of autonomously detecting mild cognitive impairment (MCI) in the older adult population. We implement a signal processing approach equipped with a machine learning paradigm to process and analyze real-world data acquired using home-based unobtrusive sensing technologies. Using the sensor and clinical data pertaining to 97 subjects, acquired over an average period of three years, a number of measures associated with the subjects´ walking speed and general activity in the home were calculated. Different time spans of these measures were used to generate feature vectors to train and test two machine learning algorithms namely support vector machines and random forests. We were able to autonomously detect MCI in older adults with an area under the ROC curve of 0.97 and an area under the precision-recall curve of 0.93 using a time window of 24 weeks. This study is of great significance since it can potentially assist in the early detection of cognitive impairment in older adults.
  • Keywords
    brain; cognition; diseases; geriatrics; learning (artificial intelligence); medical signal detection; medical signal processing; support vector machines; ROC curve; autonomous unobtrusive detection; dementia; feature vectors; home-based unobtrusive sensing technologies; machine learning algorithms; mild cognitive impairment; older adults; precision-recall curve; random forests; signal processing; support vector machines; Biomedical measurement; Dementia; Feature extraction; Legged locomotion; Monitoring; Sensors; Vectors; Home Activity; Home activity; Machine Learning; Mild Cognitive Impairment; Older Population; Signal Processing; Smart Systems; Unobtrusive Sensing Technologies; Walking Speed; machine learning; mild cognitive impairment (MCI); older population; signal processing; smart systems; unobtrusive sensing technologies; walking speed;
  • fLanguage
    English
  • Journal_Title
    Biomedical Engineering, IEEE Transactions on
  • Publisher
    ieee
  • ISSN
    0018-9294
  • Type

    jour

  • DOI
    10.1109/TBME.2015.2389149
  • Filename
    7005481