Title :
Breaking the optical difraction barrier with nanophotonics - Ultrahigh-resolution bioimaging and biosensing in the subwavelength nanometric range with nanobiophotonic technologies
Author_Institution :
Center for Devices & Radiol. Health, US Food & Drug Adm., Rockville, MD
Abstract :
The main goal of this study is to develop novel fiber-optic-based nanobiophotonics techniques for noninvasive imaging and biosensing optical properties of cellular and tissue samples beyond the diffraction barrier in the subwavelength nanoscale range. The work covers fundamental principles, recent developments, and trends in advanced nanobiophotonics techniques exploited for either minimally invasive diagnostics and imaging in biomedicine at cellular/intracellular level or development of nanosensors and nanostructured materials. Somerecently developed advanced ultrahigh-resolution nanotechnologies such as confocal nanoscopy and fiber-optic-based nanosensors, will also be discussed. These technologies allow one to break the theoretical optical diffraction barrier and to work in the subwavelength nanoscale range
Keywords :
biological tissues; biomedical optical imaging; biosensors; cellular biophysics; fibre optic sensors; light diffraction; nanotechnology; biomedicine diagnostics; biomedicine imaging; biosensing; cellular optical properties; confocal nanoscopy; fiber optic sensors; nanobiophotonics techniques; nanosensors; nanostructured materials; noninvasive imaging; optical diffraction barrier; tissue samples; ultrahigh-resolution nanotechnologies; Biomedical imaging; Biomedical optical imaging; Biophotonics; Biosensors; Fiber lasers; Laser theory; Lasers and electrooptics; Nanobioscience; Nanophotonics; Optical imaging;
Journal_Title :
Circuits and Devices Magazine, IEEE
DOI :
10.1109/MCD.2006.307278
