Drive-Field Frequency Dependent MPI Performance of Single-Core Magnetite Nanoparticle Tracers

Author

Kuhlmann, Christian ; Khandhar, Amit P. ; Ferguson, Richard Matthew ; Kemp, Scott ; Wawrzik, Thilo ; Schilling, Meinhard ; Krishnan, Kannan M. ; Ludwig, Frank

Author_Institution

Inst. of Electr. Meas. & Fundamental Electr. Eng., Tech. Univ. Braunschweig, Braunschweig, Germany

Volume

51

Issue

2

fYear

2015

fDate

Feb. 2015

Firstpage

1

Lastpage

4

Abstract

The drive-field frequency of magnetic particle imaging (MPI) systems plays an important role for system design, safety requirements, and tracer selection. Because the commonly utilized MPI drive-field frequency of 25 kHz might be increased in future system generations to avoid peripheral nerve stimulation, a performance evaluation of tracers at higher frequencies is desirable. We have studied single-core magnetite nanoparticles that were optimized for MPI applications, utilizing magnetic particle spectrometers (MPS) with drive-field frequencies in the range from 1 to 100 kHz. The particles have core diameters of 25 nm and a hydrodynamic size of 77 nm. Measurements in the frequency range above 5 kHz were carried out with a newly designed MPS system. In addition, to exclude possible particle interaction, samples of different concentrations were characterized and compared.

Keywords

hydrodynamics; image processing; iron compounds; magnetic particles; particle spectrometers; Fe₃O₄; drive-field frequency dependent MPI performance; frequency 1 kHz to 100 kHz; hydrodynamic size; magnetic particle imaging; magnetic particle spectrometers; single-core magnetite nanoparticle tracers; size 25 nm to 77 nm; Atmospheric measurements; Frequency measurement; Harmonic analysis; Magnetic particles; Magnetic resonance imaging; Particle measurements; Magnetic particle imaging; magnetic particle spectroscopy; magnetic particles; tracer performance;

fLanguage

English

Journal_Title

Magnetics, IEEE Transactions on

Publisher

ieee

ISSN

0018-9464

Type

jour

DOI

10.1109/TMAG.2014.2329772

Filename

7067481