Title :
A Minimally Invasive Microdevice for Molecular Sampling and Analysis
Author :
Cosnier, Marie-Line ; Martin, Franck ; Bouamrani, Ali ; Berger, François ; Caillat, Patrice
Author_Institution :
Electron. & Inf. Technol. Lab., French Atomic Energy Comm. Micro-Nano Technol. (CEA-LETI-MINATEC), Grenoble, France
Abstract :
In this paper, we present a new minimally invasive biopsy microdevice adapted to proteomic mass spectrometry analysis. The concept is born from a multidisciplinary collaboration in fields of proteomics, cancer research, and microtechnology. In mixing different skills, we have developed and manufactured a miniaturized biopsy device using microtechnology techniques in order to minimize tissue damage during surgical gesture. Dedicated chemically functionalized areas were added to the device in order to increase capture yield and specificity during tissue contact. Fields of application range from cancer research to the study of neurodegenerative diseases.
Keywords :
bioMEMS; biochemistry; cancer; mass spectroscopic chemical analysis; molecular biophysics; proteomics; tumours; cancer research; microtechnology techniques; minimally biopsy invasive microdevice; molecular analysis; molecular sampling; neurodegenerative diseases; proteomic mass spectrometry analysis; surgical gesture; tissue damage; Biopsy; Cancer; Collaboration; Manufacturing; Mass spectroscopy; Minimally invasive surgery; Oncological surgery; Proteomics; Sampling methods; Tissue damage; Biopsy; chemical functionalization; microtech-nology; Biopolymers; Biopsy; Computer-Aided Design; Equipment Design; Equipment Failure Analysis; Microarray Analysis; Miniaturization; Reproducibility of Results; Sensitivity and Specificity; Surgical Procedures, Minimally Invasive; Tissue Array Analysis;
Journal_Title :
Biomedical Engineering, IEEE Transactions on
DOI :
10.1109/TBME.2009.2026582
