A novel method to reconstruct central aortic pressure signal using dual-peripheral pressure waves

Reconstructing central aortic pressure (CAP) from non-invasive bio-signals is challenging. Recent studies have shown a promising reconstruction method using peripheral arterial pressure together with blood flow waves. However, blood waves cannot be readily acquired. We thus proposed a novel approach to reconstruct CAP using dual-peripheral arterial pressure waves measured from brachial and radial arteries based on the wave separation and reconstruction method. According to the widely used three-element Windkessel model (Fig. 1), we re-formulated forward and backward wave equations in frequency domain in order to derive solutions from two peripheral blood pressure waves. Our results showed that this method can accurately reconstruct CAP.