DocumentCode :
1144931
Title :
Resistance of gastric mucosa to self-digestion
Author :
Garner, Andrew
Author_Institution :
Dept. of Pharmacology & Therapeutics, United Arab Emirates Univ., Al-Ain, United Arab Emirates
Volume :
13
Issue :
4
fYear :
1994
Firstpage :
504
Lastpage :
507
Abstract :
In recent years, the view of the gastric mucosal barrier as a static entity has given way to a dynamic system, the components of which have recently been reviewed in detail. These complex anatomical and physiological properties are conveniently divided into three categories. The major extrinsic factor is the pre-epithelial mucus-bicarbonate barrier, which provides a first line of defence. Intrinsic protection residing with the mucosal cells per se, involves cytoplasmic pH homeostasis together with epithelial restitution and regeneration. Finally, postepithelial factors within the submucosa and interstitium include the microvasculature and maintenance of acid-base balance.<>
Keywords :
cellular biophysics; acid-base balance maintenance; complex physiological properties; cytoplasmic pH homeostasis; dynamic system; epithelial regeneration; epithelial restitution; gastric mucosa resistance; interstitium; microvasculature; mucosal cells; postepithelial factors; pre-epithelial mucus-bicarbonate barrier; self-digestion; Biochemistry; Blood; Cells (biology); Displays; Drugs; Fluids and secretions; Protection; Proteins; Protons; Stomach;
fLanguage :
English
Journal_Title :
Engineering in Medicine and Biology Magazine, IEEE
Publisher :
ieee
ISSN :
0739-5175
Type :
jour
DOI :
10.1109/51.310991
Filename :
310991
Link To Document :
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