A Model for the Formation of Direction-Selective Cells in Developing Retina

A model for the direction-selective cells in the retina is proposed. In this model an axon of the outer horizontal cell extending laterally in one direction forms synapses with the amacrine cells and inhibits their potential. These amacrine cells hyperpolarize the ganglion cells and produce their direction-selectivity. The development of the axon of the outer horizontal cell makes a difference in the respective strength among synapses connecting bipolar cells, amacrine cells, and ganglion cells which enhance the direction-selectivity. The model was simulated in a computer.