Title :
Modular design for in vivo optical imaging and ultrasound treatment in the murine brain
Author :
Raymond, Scott B. ; Skoch, Jesse ; Bacskai, Brian J. ; Hynynen, Kullervo
Author_Institution :
Div. of Health Sci. & Tech., MIT, Boston, MA
fDate :
2/1/2007 12:00:00 AM
Abstract :
Simultaneous optical imaging and ultrasound exposure to the brain is challenging due to geometric constraints. We demonstrate sonication through the ventral surface of the mouse, leaving the dorsal aspect free for imaging. Ultrasound components are integrated into a commercial multiphoton microscope, and animals are imaged during ultrasound-induced blood-brain barrier disruption
Keywords :
biomedical optical imaging; biomedical ultrasonics; blood; brain; patient treatment; blood-brain barrier disruption; commercial multiphoton microscope; in vivo optical imaging; modular design; mouse ventral surface; murine brain; sonication; ultrasound exposure; ultrasound treatment; Acoustic transducers; Focusing; In vivo; Mice; Microscopy; Optical design; Optical imaging; Skull; Ultrasonic imaging; Ultrasonic transducers; Animals; Blood-Brain Barrier; Brain; Equipment Design; Equipment Failure Analysis; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence, Multiphoton; Sonication; Systems Integration; Ultrasonic Therapy;
Journal_Title :
Ultrasonics, Ferroelectrics, and Frequency Control, IEEE Transactions on
DOI :
10.1109/TUFFC.2007.257
