DocumentCode
115915
Title
Modelling essential interactions between synthetic genes and their chassis cell
Author
Algar, R.J.R. ; Ellis, T. ; Stan, G.-B.
Author_Institution
Dept. of Bioeng., Imperial Coll. London, London, UK
fYear
2014
fDate
15-17 Dec. 2014
Firstpage
5437
Lastpage
5444
Abstract
In this paper we develop a model of gene expression for the purpose of studying the resource use of synthetic gene circuits when expressed in chassis cells. This model focuses on the translational aspect of gene expression which accounts for the majority of resource usage. The model allows for simulations of circuit-chassis interactions that can be used to inform improved designs of synthetic gene circuits.
Keywords
biology; cellular biophysics; genetics; chassis cell; circuit-chassis interaction simulation; essential interaction modeling; gene expression translational aspect; synthetic gene circuits; Biological system modeling; Equations; Erbium; Integrated circuit modeling; Mathematical model; Random variables; Synthetic biology; Circuit-Chassis Interactions; Ribosomal Availability; Synthetic Biology; Translational Model;
fLanguage
English
Publisher
ieee
Conference_Titel
Decision and Control (CDC), 2014 IEEE 53rd Annual Conference on
Conference_Location
Los Angeles, CA
Print_ISBN
978-1-4799-7746-8
Type
conf
DOI
10.1109/CDC.2014.7040239
Filename
7040239
Link To Document