Title :
Magnetic biosensors for genetic screening of cystic fibrosis
Author :
Lagae, L. ; Wirix-Speetjens, R. ; Liu, C.-X. ; Laureyn, W. ; Borghs, G. ; Harvey, S. ; Galvin, P. ; Ferreira, H.A. ; Graham, D.L. ; Freitas, P.P. ; Clarke, L.A. ; Amaral, M.D.
Author_Institution :
IMEC/MCP, Leuven, Belgium
Abstract :
The paper reports on the development of a magnetic biosensing platform for genetic analysis. The sensing technique is based on the on-chip manipulation of magnetically labelled biomolecules by the magnetic field gradient force created by current-carrying conductors; on biomolecular reactions such as the binding of complementary DNA material; and on the detection of the fringe field of the magnetic label by a magnetoresistive spin valve sensor. Different experiments will demonstrate the advantages, difficulties, prospects and potential of the combination of magnetic bead manipulation and detection on a single microchip. Early detection of DNA coding for the cystic fibrosis (CF) gene is used as a model system for proof-of-concept of the magnetic DNA biosensor platform.
Keywords :
DNA; biological techniques; biomagnetism; biosensors; genetics; magnetic sensors; patient diagnosis; spin valves; DNA coding; biomolecular reactions; complementary DNA material; current-carrying conductors; cystic fibrosis gene; fringe field detection; genetic analysis; genetic screening; magnetic DNA biosensor; magnetic bead detection; magnetic bead manipulation; magnetic field gradient force; magnetic label; magnetically labelled biomolecules; magnetoresistive spin valve sensor; on-chip manipulation; sensing techniques;
Journal_Title :
Circuits, Devices and Systems, IEE Proceedings -
DOI :
10.1049/ip-cds:20050022
