A fully electronic DNA sensor with 128 positions and in-pixel A/D conversion

Author

Schienle, Meinrad ; Paulus, Christian ; Frey, Alexander ; Hofmann, Franz ; Holzapfl, Birgit ; Schindler-Bauer, Petra ; Thewes, Roland

Author_Institution

Corporate Res., Infineon Technol. AG, Munich, Germany

Volume

39

Issue

12

fYear

2004

Firstpage

2438

Lastpage

2445

Abstract

A 16 × 8 sensor array chip for fully electronic DNA detection is presented. The sensor principle is based on an electrochemical redox cycling process. The chip is fabricated on the basis of an extended 0.5 μm CMOS process. Each sensor site of the array chip contains a complete A/D converter with a dynamic range of five decades. The 3σ-homogeneity of the electrical response of the sensor array is better than 6% (10^-11 A to 10^-7 A) and better than 20% (10^-12 A to 10^-7 A). Proper operation of the chip is demonstrated with electrochemical and biological experiments.

Keywords

CMOS integrated circuits; DNA; analogue-digital conversion; arrays; biosensors; electric current measurement; microelectrodes; transducers; 1E-10 to 1E-6 A; 1E-11 to 1E-6 A; A/D conversion; CMOS integrated circuits; DNA detection; DNA sensor; chemical transducers; current measurement; drugs; electrochemical devices; electrochemical redox cycling; microelectrodes; sensor array chip; Biomedical optical imaging; Circuits; Current measurement; DNA; Drugs; Dynamic range; Optical sensors; Probes; Sensor arrays; Sequences; 65; CMOS integrated circuits; DNA; chemical transducers; current measurement; drugs; electrochemical devices; microelectrodes;

fLanguage

English

Journal_Title

Solid-State Circuits, IEEE Journal of

Publisher

ieee

ISSN

0018-9200

Type

jour

DOI

10.1109/JSSC.2004.837084

Filename

1362854