256-Channel Neural Recording and Delta Compression Microsystem With 3D Electrodes

Author

Aziz, Joseph N Y ; Abdelhalim, Karim ; Shulyzki, Ruslana ; Genov, Roman ; Bardakjian, Berj L. ; Derchansky, Miron ; Serletis, Demitre ; Carlen, Peter L.

Author_Institution

Dept. of Electr. & Comput. Eng., Univ. of Toronto, Toronto, ON

Volume

44

Issue

3

fYear

2009

fDate

3/1/2009 12:00:00 AM

Firstpage

995

Lastpage

1005

Abstract

A 3D microsystem for multi-site penetrating extracellular neural recording from the brain is presented. A 16 times 16-channel neural recording interface integrated prototype fabricated in 0.35 mum CMOS occupies 3.5 mm times 4.5 mm area. Each recording channel dissipates 15 muW of power with input-referred noise of 7 muV_rms over 5 kHz bandwidth. A switched-capacitor delta read-out data compression circuit trades recording accuracy for the output data rate. An array of 1.5 mm platinum-coated microelectrodes is bonded directly onto the die. Results of in vitro experimental recordings from intact mouse hippocampus validate the circuit design and the on-chip electrode bonding technology.

Keywords

CMOS integrated circuits; data compression; electrodes; medical signal processing; recording; 3D electrodes; 3D microsystem; CMOS process; circuit design; delta compression microsystem; frequency 5 kHz; neural recording; on-chip electrode bonding technology; power 15 muW; size 0.35 mum; switched-capacitor delta read-out data compression circuit; Bandwidth; Bonding; Data compression; Electrodes; Extracellular; In vitro; Mice; Microelectrodes; Prototypes; Switching circuits; Multi-channel recording; brain; delta compression; electrode array; extracellular recording; hippocampus; implantable; microelectrodes; neural amplifier;

fLanguage

English

Journal_Title

Solid-State Circuits, IEEE Journal of

Publisher

ieee

ISSN

0018-9200

Type

jour

DOI

10.1109/JSSC.2008.2010997

Filename

4787578