Immunology and disease control: a systems approach

Author

Asachenkov, Alexander L. ; Marchuk, Gurij I. ; Mohler, Ronald R. ; Zuev, Sergei M.

Author_Institution

Dept. of Syst. & Decision Sci., Int. Inst. for Appl. Syst. Anal., Laxenburg, Austria

Volume

41

Issue

10

fYear

1994

Firstpage

943

Lastpage

953

Abstract

The application of system theory (or more precisely, differential equations) to immunology and disease, in general, is presented here. Particular results from U.S.-Russian research collaboration depict the potential role of such systematic analysis for more effective health care and disease control. In particular, some emphasis is given to control of influenza. After a brief systematic overview of immunology, a simple infectious disease model is developed to explain four basic forms of disease: subclinical, acute, lethal and chronic. Then, disease treatment is studied.

Keywords

biocontrol; differential equations; physiological models; U.S.-Russian research collaboration; acute disease; chronic disease; disease control; disease treatment; effective health care; immunology; influenza control; lethal disease; simple infectious disease model; subclinical disease; Cells (biology); Control systems; Differential equations; Diseases; Immune system; Influenza; Medical services; Pathogens; Plasmas; Viruses (medical); Acute Disease; Chronic Disease; Communicable Diseases; Computer Simulation; Humans; Influenza, Human; Models, Biological; Systems Theory;

fLanguage

English

Journal_Title

Biomedical Engineering, IEEE Transactions on

Publisher

ieee

ISSN

0018-9294

Type

jour

DOI

10.1109/10.324526

Filename

324526