Title :
Numerical simulation of protein stamping process driven by capillary force
Author :
Lin, Shih-Chang ; Tseng, Fangang ; Chieng, Ching-Chang
Author_Institution :
Dept. of Eng. & Syst. Sci., Nat. Tsing Hua Univ., Hsinchu, Taiwan
Abstract :
Numerical simulations based on first-principle conservation laws of mass and momentum are performed to observe flow characteristics during the stamping process. The protein solution is transferred by a new design of microstamps with microchannels and printed on a bottom substrate. Furthermore, key physics of the stamping process and the control factors achieving uniform spot size can be identified and optimized after these simulations.
Keywords :
biological techniques; biosensors; capillarity; channel flow; microfluidics; molecular biophysics; numerical analysis; proteins; surface tension; biosensors; bottom substrate; capillary force; control factors; first-principle conservation laws; flow characteristics; mass; medical diagnostics; microchannels; microstamps; momentum; numerical simulation; protein solution; protein stamping process; uniform spot size; Microchannel; Microfluidics; Numerical simulation; Physics; Printing; Process control; Protein engineering; Size control; Soft lithography; Systems engineering and theory;
Journal_Title :
NanoBioscience, IEEE Transactions on
DOI :
10.1109/TNB.2003.809463
