Synthesis of MRI contrast agent by coating superparamagnetic iron oxide with chitosan

Author

Lee, HyoSook ; Shao, Huiping ; Huang, Yuqiang ; Kwak, ByungKook

Author_Institution

Korea Inst. of Geol., Min., & Mater., Daejeon, South Korea

Volume

41

Issue

10

fYear

2005

Firstpage

4102

Lastpage

4104

Abstract

Ultrasuperpara magnetic iron oxide (USPIO) nanoparticles were synthesized with iron chloride using a sonochemical method. The size of the USPIO nanoparticles was controlled by ultrasonic exposure time and power. The USPIO nanoparticles had a narrow size distribution, a perfect magnetite crystal structure, and high saturation magnetization. The magnetic resonance imaging (MRI) contrast agent was prepared by coating the USPIO and dispersing it with biocompatible chitosan. In vivo testing in New Zealand white rabbits confirmed the effectiveness of the USPIO nanoparticles as a MRI contrast agent.

Keywords

biomedical MRI; iron compounds; magnetic particles; nanoparticles; paramagnetic materials; MRI contrast agent; USPIO nanoparticles; biocompatible chitosan; magnetic resonance imaging; perfect magnetite crystal structure; saturation magnetization; sonochemical method; sonochemistry; ultra superparamagnetic iron oxide; Coatings; In vivo; Iron; Magnetic materials; Magnetic resonance imaging; Nanoparticles; Rabbits; Saturation magnetization; Stability; Testing; In vivo; magnetic resonance imaging (MRI) contrast agent; nano-size; sonochemistry; ultrasuperpara magnetic iron oxide (USPIO)-chitosan;

fLanguage

English

Journal_Title

Magnetics, IEEE Transactions on

Publisher

ieee

ISSN

0018-9464

Type

jour

DOI

10.1109/TMAG.2005.855338

Filename

1519549