Title :
Magnetic resonance of polyaspartic acid-coated magnetite nanoparticles administered in mice
Author :
Sadeghiani, N. ; Barbosa, L.S. ; Guedes, M.H.A. ; Chaves, S.B. ; Santos, J.G. ; Silva, O. ; Pelegrini, F. ; Azevedo, R.B. ; Morais, P.C. ; Lacava, Z.G.M.
Author_Institution :
Univ. de Brasflia, Brasflia-DF, Brazil
Abstract :
Magnetic resonance (MR) was used in the biodistribution investigation of magnetic nanoparticles (MNPs) surface-coated with polyaspartic acid (PAMF), developed as a biocompatible magnetic fluid (BMF) sample. The data allowed us to obtain the kinetic parameters for MNP disposition from the blood and its uptake by the liver, spleen, and lungs. Light microscopy confirmed the MR results. Genetic and toxicity tests showed that the PAMF is reasonable biocompatible. The PAMF sample presented peculiar biodistribution patterns and may be considered as a potential precursor of anticancer drugs.
Keywords :
biological techniques; magnetic fluids; magnetic particles; magnetic resonance; nanoparticles; anticancer drugs; biocompatible magnetic fluid; biodistribution patterns; gentic/toxicity tests; light microscopy; magnetic resonance; magnetite nanoparticles; nanoparticle biodistribution; polyaspartic acid; Blood; Genetics; Kinetic theory; Liver; Lungs; Magnetic liquids; Magnetic resonance; Mice; Microscopy; Nanoparticles; Magnetic fluid (MF); magnetic resonance (MR); nanoparticle biodistribution; polyaspartic acid (PA);
Journal_Title :
Magnetics, IEEE Transactions on
DOI :
10.1109/TMAG.2005.855334
