Title :
In vivo and in vitro investigation of photosensitizer-adsorbed superparamagnetic nanoparticles for photodynamic therapy
Author :
Park, S.I. ; Lim, J.H. ; Kim, J.H. ; Yun, H.I. ; Kim, C.O.
Author_Institution :
Dept. of Mater. Eng., Chungnam Nat. Univ., Daejeon, South Korea
Abstract :
Superparamagnetic particles of Fe3O4 were nanometrically synthesized by coprecipitation. Hematoporphyrin (HP) and 5-aminolevulinic acid (ALA) were used as photosensitizers, which were adsorbed on magnetic particles. The adsorption rates of HP and ALA were observed to 2.0% and 12.5% by UV spectrometry and the pico-tag method, respectively. The toxicity of the magnetic fluids was estimated using Sprague-Dawley rats. The photodynamic effect of the photosensitizer-adsorbed magnetic fluids was examined with a human lung cancer cell, for which the light doses were applied to 400 mJ/cm3.
Keywords :
cancer; cellular effects of radiation; iron compounds; magnetic fluids; magnetic particles; nanoparticles; paramagnetic materials; photodynamic therapy; precipitation; ultraviolet spectrometers; 5-aminole-vulinic acid; Fe3O4; Sprague-Dawley rats; UV spectrometry; cancer cell; coprecipitation; hematoporphyrin; magnetic fluids toxicity; magnetic particle; photodynamic effect; photodynamic therapy; photosensitizer; pico-tag method; superparamagnetic nanoparticles; Humans; In vitro; In vivo; Iron; Magnetic liquids; Magnetic particles; Medical treatment; Nanoparticles; Rats; Spectroscopy; Cancer cell; in vitro; in vivo; magnetic particle; photodynamic therapy; photosensitizer;
Journal_Title :
Magnetics, IEEE Transactions on
DOI :
10.1109/TMAG.2005.854462
