Surface modification of hydrophobic iron oxide nanoparticles for clinical applications

Author

Woo, Kyoungja ; Hong, Jangwon

Author_Institution

Nano-Mater. Res. Center, Korea Adv. Energy Res. Inst., Seoul, South Korea

Volume

41

Issue

10

fYear

2005

Firstpage

4137

Lastpage

4139

Abstract

Monodisperse superparamagnetic iron oxide nanoparticles (SPIONs) were prepared by thermal decomposition of Fe(CO)₅ and by consecutive aeration in organic medium. The resultant hydrophobic SPION surface was modified to be hydrophilic via Fe-S covalent bond with bi-functional 3-mercaptopropionic acid and then, the terminal carboxylic acid group was esterified with dextran for biocompatibility. Analysis by water dispersity, transmission electron microscopy, X-ray diffraction, and Fourier transformed infrared spectroscopy are reported.

Keywords

Fourier transform spectroscopy; X-ray diffraction; iron compounds; magnetic materials; nanoparticles; pyrolysis; superparamagnetism; surface morphology; transmission electron microscopy; 3-mercaptopropionic acid; Fe(CO)₅; Fourier transformed infrared spectroscopy; X-ray diffraction; biocompatibility; carboxylic acid; clinical applications; hydrophobic iron oxide nanoparticles; monodisperse superparamagnetic iron oxide nanoparticles; surface modification; thermal decomposition; transmission electron microscopy; water dispersity; Bonding; Electrons; Iron; Magnetic separation; Nanoparticles; Nitrogen; Polymers; Protection; Temperature; Thermal decomposition; Iron oxide; nanoparticles; superparamagnetic; surface modification;

fLanguage

English

Journal_Title

Magnetics, IEEE Transactions on

Publisher

ieee

ISSN

0018-9464

Type

jour

DOI

10.1109/TMAG.2005.855343

Filename

1519559