Title :
Expediting magnetic separation using Ni Wires,Applicable for robot-manipulated bio-screening systems
Author :
Shimazu, Ryuichi ; Tada, Masaru ; Matsushita, Nobuhiro ; Handa, Hiroshi ; Abe, Masanori
Author_Institution :
Dept. of Phys. Electron., Tokyo Inst. of Technol., Japan
Abstract :
We developed a novel millimeter sized high gradient magnetic separation (HGMS) device for robot-manipulated bio-screening systems where test liquids containing magnetic nanobeads are processed in mm-sized container arrays in wells. Two hundred Ni wires (200μmφ× 30mm) were bundled together to make a tubular brush (6.7mm and 8.4mm in inner and outer diameters), which was set in a container (8.8mmφ× 45mm in inner size) to enhance the magnetic field gradient. Application of an external field of 0.3T (a value attainable using NdFeB magnets) enabled separation of magnetic particles having an average diameter of 30nm, at a recapture rate of 98%, in three minutes. Theoretical calculations based on a simple model confirmed the validity of the results.
Keywords :
biomedical equipment; magnetic particles; magnetic separation; nanowires; nickel; 0.3 T; 200 micron; 30 mm; 30 nm; 6.7 mm; 8.4 mm; ferrite nanoparticles; high gradient magnetic separation; magnetic field gradient; magnetic nanobeads; magnetic particles; robot-manipulated bio-screening systems; tubular brush; Brushes; Containers; Magnetic devices; Magnetic liquids; Magnetic separation; Millimeter wave devices; Nanoscale devices; Robots; System testing; Wires; Bio-screening; ferrite nanoparticles; high gradient magnetic separation; magnetic separation;
Journal_Title :
Magnetics, IEEE Transactions on
DOI :
10.1109/TMAG.2005.855342
