Title :
Biodistribution of chitosan-based magnetite suspensions for targeted hyperthermia in ICR mice
Author :
Kim, Dong-Hyun ; Lee, Se-Ho ; Im, Ki-Hyeong ; Kim, Kyoung-Nam ; Kim, Kwang-Mahn ; Kim, Kee-Deog ; Park, Hyok ; Shim, In-Bo ; Lee, Yong-Keun
Author_Institution :
Dept. & Res. Inst. of Dental Biomaterials & & Bioeng., Yonsei Univ. Coll. of Dentistry, Seoul, South Korea
Abstract :
Magnetite and the chitosan-based magnetite suspensions were synthesized by spray-coprecipitation. In the 2 wt% chitosan-based magnetite suspension, the zeta-potential value was lower value at 5.6 mV relative to other concentrations of magnetic suspension. The chitosan-based magnetic suspension with a zeta potential close to zero showed increased circulation time in biodistribution of Institute of Cancer Research mice.
Keywords :
biomedical materials; cancer; electrokinetic effects; hyperthermia; magnetic fluids; precipitation; 5.6 mV; ICR mice; biodistribution; biomedical materials; cancer; chitosan; hyperthermia; magnetic liquids; magnetite suspensions; spray coprecipitation; zeta potential; Dentistry; Hyperthermia; Iron; Magnetic levitation; Magnetic materials; Mice; Saturation magnetization; Spraying; Suspensions; USA Councils; Biomedical materials; cancer; hyperthermia; magnetic liquids;
Journal_Title :
Magnetics, IEEE Transactions on
DOI :
10.1109/TMAG.2005.854857
