Title :
Novel superparamagnetic Core(Shell) nanoparticles for magnetic targeted drug delivery and hyperthermia treatment
Author :
Gangopadhyay, Palash ; Gallet, Sébastien ; Franz, Edith ; Persoons, André ; Verbiest, Thierry
Author_Institution :
Dept. of Chem., Catholic Univ. of Leuven, Heverlee, Belgium
Abstract :
Superparamagnetic γ-Fe2O3(Au) core(shell) nanoparticles with narrow size distribution and different shell thicknesses are synthesized. On conjugation with serum albumin, this set of particles forms an ideal candidate to be used in magnetic targeted drug delivery and hyperthermia treatment. In this contribution, the synthesis and characterizations of their size, optical, and magnetic properties are reported. It has also been shown that using different shell thicknesses, it is possible to tune not only the plasmon response of the gold shell but also the magnetic property of these superparamagnetic nanoparticles.
Keywords :
drug delivery systems; hyperthermia; iron compounds; magnetic particles; nanoparticles; patient treatment; superparamagnetism; Fe2O3Au; core/shell nanoparticles; hyperthermia treatment; magnetic properties; magnetic targeted drug delivery; optical properties; plasmon response; serum albumin; shell thickness; size characterization; superparamagnetic nanoparticles; Cancer; Drug delivery; Gold; Hyperthermia; Magnetic cores; Magnetic materials; Magnetic properties; Nanoparticles; Plasmons; Targeted drug delivery; Core(shell) nanoparticles; hyperthermia; maghemite (gold); magnetic targeted drug delivery;
Journal_Title :
Magnetics, IEEE Transactions on
DOI :
10.1109/TMAG.2005.854805
