Title :
Control of neuromuscular blockade in the presence of sensor faults
Author :
Lemos, João M. ; Magalhães, Hugo ; Mendonça, Teresa ; Dionisio, Rui
Author_Institution :
INESC-ID/IST, Lisboa, Portugal
Abstract :
The problem of embedding sensor fault tolerance in feedback control of neuromuscular blockade is considered. For tackling interruptions of feedback measurements, a structure based upon Bayesian inference as well as a predictive filter is proposed. This algorithm is general and can be applied to different situations. Here, it is incorporated in an adaptive automatic system for feedback control of neuromuscular blockade using continuous infusion of muscle relaxants. A significant contribution consists in the experimental clinical testing of the algorithm in patients undergoing surgery.
Keywords :
Bayes methods; biocontrol; feedback; median filters; medical signal processing; muscle; neurophysiology; sensors; surgery; Bayesian inference; feedback control; muscle relaxants; neuromuscular blockade; predictive filter; sensor fault tolerance; Adaptive control; Adaptive systems; Bayesian methods; Fault tolerance; Feedback control; Filters; Inference algorithms; Neurofeedback; Neuromuscular; Programmable control; Bayes inference; hybrid systems; median filter; neuromuscular blockade; outliers; physiological systems; supervisory multiple models control; Algorithms; Computer Simulation; Drug Therapy, Computer-Assisted; Electromyography; Feedback; Humans; Models, Neurological; Motor Neurons; Muscle, Skeletal; Neuromuscular Blockade; Neuromuscular Blocking Agents; Synaptic Transmission;
Journal_Title :
Biomedical Engineering, IEEE Transactions on
DOI :
10.1109/TBME.2005.856259
