A Fully Electronic Label-Free DNA Sensor Chip

Author

Stagni, Claudio ; Guiducci, Carlotta ; Benini, Luca ; Riccò, Bruno ; Carrara, Sandro ; Paulus, Christian ; Schienle, Meinrad ; Thewes, Roland

Author_Institution

Dept. of Electr. Eng. & Comput. Sci., Bologna Univ.

Volume

7

Issue

4

fYear

2007

fDate

4/1/2007 12:00:00 AM

Firstpage

577

Lastpage

585

Abstract

This paper presents a microfabricated DNA chip for fully electronic, label-free DNA recognition based on capacitance measurements. The chip has been fabricated in 0.5-mum CMOS technology and it features an array of individually addressable sensing sites consisting of pairs of gold electrodes and addressing logic. Read-out circuitry is built externally using standard components to provide increased experimental flexibility. The chip has been electrically characterized and tested with various solutions containing DNA samples. Significant capacitance variations due to DNA hybridization have been measured, thus showing that the approach represents a viable solution for a single chip DNA sensor array

Keywords

CMOS integrated circuits; DNA; biosensors; capacitance measurement; electrodes; 0.5 micron; CMOS technology; DNA hybridization; DNA samples; DNA sensor arrays; addressing logic; capacitance measurements; fully electronic label-free DNA recognition; fully electronic label-free DNA sensor chip; gold electrodes; hybridization label-free detection; microfabricated DNA chip; read-out circuitry; CMOS logic circuits; CMOS technology; Capacitance measurement; Circuit testing; DNA; Electrodes; Flexible printed circuits; Gold; Logic arrays; Sensor arrays; Capacitance measurement; DNA sensor arrays; hybridization label-free detection;

fLanguage

English

Journal_Title

Sensors Journal, IEEE

Publisher

ieee

ISSN

1530-437X

Type

jour

DOI

10.1109/JSEN.2007.891990

Filename

4118162