Title :
Regulation of a Physiological Parameter or In Vivo Drug Concentration by Integral Pulse Frequency Modulated Bolus Drug Injections
Author :
Northrop, Robert B. ; Woodruff, Eileen A.
Author_Institution :
Biomedical Engineering Laboratories, U-157, and the Department of Electrical Engineering and Computer Science, University of Connecticut
Abstract :
This paper describes the designs for two novel, nonlinear, discrete, drug injection controllers. The basis for these controllers is integral pulse frequency modulation (IPFM). An IPFM controller injects small boluses of a drug into a pharmacokinetic (PK) plant to achieve regulation of the plant output. Bolus injections are advantageous because they provide a precise knowledge of the times and the cumulative amount of drug injected, and they require a discrete-action pump suitable for digital control, miniaturization, and implantation.
Keywords :
Biological system modeling; Cancer; Control systems; Drugs; Frequency modulation; In vivo; Insulin; Plasma simulation; Pulse modulation; Pumps; Computers; Humans; Infusion Pumps; Insulin; Insulin Infusion Systems; Kinetics; Methotrexate; Microcomputers; Pharmaceutical Preparations;
Journal_Title :
Biomedical Engineering, IEEE Transactions on
DOI :
10.1109/TBME.1986.325867