Title :
Laser backscattering and transillumination imaging of human tissues and their equivalent phantoms
Author :
Srinivasan, R. ; Singh, Megha
Author_Institution :
Biomed. Eng. Div., Indian Inst. of Technol., Chennai, India
fDate :
6/1/2003 12:00:00 AM
Abstract :
Surface backscattering profiles from a human forearm and transmission profiles through a human thumb, of red and near-infrared lasers, were determined. For the preparation of tissue-equivalent phantoms, white paraffin wax mixed with various wax color pigments were used. The surface reflectance profiles of a human forearm were matched with that of the phantom by mixing color pigments in various proportions. The reconstructed surface reflectance image of the phantom prepared by this procedure was similar to that of the human forearm. The transmission tomogram of the human thumb was obtained in fan-beam configuration by a near-infrared laser tomography system. Based on the horizontal scan of this tomogram, a two-layered phantom was made. The color composition of the phantom was so adjusted that its horizontal scan was matched with that of the thumb tomogram. The phantoms of complex tissues, prepared by this procedure, could be used for evaluation and calibration of new optical diagnostic imaging techniques.
Keywords :
biological tissues; biomedical optical imaging; calibration; infrared imaging; laser applications in medicine; light scattering; optical tomography; phantoms; color pigments mixing; complex tissues; fan-beam configuration; horizontal scan; human complex tissues; human forearm; medical diagnostic imaging; near-infrared laser tomography system; optical diagnostic imaging techniques calibration; reconstructed surface reflectance image; surface reflectance profiles; thumb tomogram; Backscatter; Humans; Image reconstruction; Imaging phantoms; Optical imaging; Pigments; Reflectivity; Surface emitting lasers; Surface reconstruction; Thumb; Equipment Design; Fiber Optics; Forearm; Humans; Lasers; Male; Optics; Phantoms, Imaging; Reproducibility of Results; Scattering, Radiation; Sensitivity and Specificity; Thumb; Tomography;
Journal_Title :
Biomedical Engineering, IEEE Transactions on
DOI :
10.1109/TBME.2003.812188