An Open Two-Compartment Model for a Double Site of Drug Absorption

An open two-compartment model with a double site of drug absorption along the gastrointestinal tract is proposed to describe the pharmacokinetics of a new drug, veralipride. We give the analytical expression of the amount of drug, at any time, in the central compartment after successive oral solution administrations. By computer simulations, plasma level profiles are obtained, which show rebounds and secondary peaks, according to experimental data.