• DocumentCode
    1220358
  • Title

    An Organ Cryopreservation Apparatus

  • Author

    O´callaghan, Michael G. ; Cravalho, Ernest G. ; Hugging, Charles E.

  • Author_Institution
    Cryogenic Engineering Laboratory, Department of Mechanical Engineering, Massachusetts Institute of Technology
  • Issue
    2
  • fYear
    1977
  • fDate
    3/1/1977 12:00:00 AM
  • Firstpage
    111
  • Lastpage
    115
  • Abstract
    Hardware necessary for cryopreservation of the isolated rat heart is described, consisting of a perfusion system and a temperature controller. The controller automatically impresses a linear temperature-time profile on the organ system with a temperature range of +40°C to -40°C. It is of the analog feedback type and features both rate and proportional feedback. Maximum temperature rate of change is ±8°C/min with this system and long term stability is ±0.5°C over 24 h. Biological applications of this device are discussed.
  • Keywords
    Automatic control; Control systems; Heart; Immune system; Output feedback; Servomechanisms; Surgery; Temperature control; Thermal resistance; Voltage; Animals; Heart; Hypothermia, Induced; Mathematics; Organ Preservation; Perfusion; Rats; Tissue Preservation;
  • fLanguage
    English
  • Journal_Title
    Biomedical Engineering, IEEE Transactions on
  • Publisher
    ieee
  • ISSN
    0018-9294
  • Type

    jour

  • DOI
    10.1109/TBME.1977.326113
  • Filename
    4122655
    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=49&DC=1220358