Title :
An Organ Cryopreservation Apparatus
Author :
O´callaghan, Michael G. ; Cravalho, Ernest G. ; Hugging, Charles E.
Author_Institution :
Cryogenic Engineering Laboratory, Department of Mechanical Engineering, Massachusetts Institute of Technology
fDate :
3/1/1977 12:00:00 AM
Abstract :
Hardware necessary for cryopreservation of the isolated rat heart is described, consisting of a perfusion system and a temperature controller. The controller automatically impresses a linear temperature-time profile on the organ system with a temperature range of +40°C to -40°C. It is of the analog feedback type and features both rate and proportional feedback. Maximum temperature rate of change is ±8°C/min with this system and long term stability is ±0.5°C over 24 h. Biological applications of this device are discussed.
Keywords :
Automatic control; Control systems; Heart; Immune system; Output feedback; Servomechanisms; Surgery; Temperature control; Thermal resistance; Voltage; Animals; Heart; Hypothermia, Induced; Mathematics; Organ Preservation; Perfusion; Rats; Tissue Preservation;
Journal_Title :
Biomedical Engineering, IEEE Transactions on
DOI :
10.1109/TBME.1977.326113
