Title :
Optimal fitting of computer model simulations to first transit cardiac radionuclide curves. II
Author :
Low, Lorry R. ; Farison, James B. ; Windham, Joe P. ; Potvin, William J.
Author_Institution :
Dept. of Radiol., Med. Coll. of Ohio, Toledo, OH, USA
Abstract :
For pt.I see ibid., vol.36, no.9, p.935-45 (1989). A discrete-time, lumped-parameter mathematical model of the human cardiopulmonary circulation as it appears during a first-transit radionuclide study was described in pt.I. An optimal fitting process is used to match curves obtained from the model to curves obtained from first transit studies in order to estimate the parameters of the subject´s heart. The development of the optimization technique is described. The results of testing the effects of overlapping compartments and errors in delay estimates are presented. A parameter determination analysis is performed by applying the optimization algorithm to simulated data. This analysis technique provides a method of estimating many parameters of heart function using a single, simple, rapid procedure.
Keywords :
cardiology; digital simulation; medical diagnostic computing; optimisation; physiological models; radioisotope scanning and imaging; computer model simulations; discrete-time model; first transit cardiac radionuclide curves; heart function parameters; human cardiopulmonary circulation; lumped-parameter mathematical model; nuclear medicine; optimal fitting process; optimization algorithm; parameter determination analysis; Cardiology; Computational modeling; Computer simulation; Curve fitting; Delay estimation; Heart; Humans; Mathematical model; Parameter estimation; Testing; Algorithms; Computer Simulation; Heart; Humans; Models, Cardiovascular; Research Design;
Journal_Title :
Biomedical Engineering, IEEE Transactions on
