Title :
An electronic device for triggering a stimulator during membrane responsiveness determinations in cardiac tissues
Author :
Pruett, J.K. ; Francis, W.W.
Author_Institution :
Dept. of Anesthesiology, Med. Coll. of Georgia, Augusta, GA, USA
fDate :
5/1/1988 12:00:00 AM
Abstract :
A device is described that monitors the repolarization phase of a cardiac action potential and compares the membrane potential to a voltage selected by the investigator. When the voltages are the same, the device triggers a stimulator that injects the stimulus at the desired membrane potential. The device can stimulate tissue at any membrane potential during the repolarization phase of the action potential between 0 and -100 mV without regard to action potential duration. When it is precisely calibrated, its accuracy is within +or-1.0 mV.
Keywords :
bioelectric potentials; biological techniques and instruments; biomembranes; cardiology; 0 to -100 mV; biological instrumentation; cardiac action potential repolarisation phase; cardiac tissues; electronic device; membrane potential; membrane responsiveness determination; stimulator triggering; Biomembranes; Delay effects; Drugs; Operational amplifiers; Optical fiber devices; Pulse amplifiers; Switches; Temperature; Time measurement; Voltage; Action Potentials; Animals; Dogs; Electric Stimulation; Equipment Design; Heart;
Journal_Title :
Biomedical Engineering, IEEE Transactions on