DocumentCode
1245827
Title
Microchip technology in ion-channel research
Author
Sigworth, Fred J. ; Klemic, Kathryn G.
Author_Institution
Dept. of Cellular & Molecular Physiol., Yale Univ., New Haven, CT, USA
Volume
4
Issue
1
fYear
2005
fDate
3/1/2005 12:00:00 AM
Firstpage
121
Lastpage
127
Abstract
The electrical activity of living cells can be monitored in various ways, but for the study of ion channels and the drugs that affect them, the patch-clamp techniques are the most sensitive. Recent developments in microfabricated patch-clamp electrodes are reviewed, and technical challenges for the future are discussed.
Keywords
bioelectric phenomena; biological techniques; biomembrane transport; micromechanical devices; reviews; drugs; electrical activity; ion channel; living cells; microchip technology; microfabricated patch-clamp electrodes; patch-clamp techniques; review; Biomembranes; Drugs; Electrodes; Heart; Monitoring; Muscles; Pharmaceutical technology; Proteins; Testing; Voltage; Amplifier noise; bioelectric phenomena; biomembranes; micromachining; Action Potentials; Cell Culture Techniques; Equipment Design; Ion Channel Gating; Ion Channels; Membrane Potentials; Microchip Analytical Procedures; Nanotechnology; Patch-Clamp Techniques; Research;
fLanguage
English
Journal_Title
NanoBioscience, IEEE Transactions on
Publisher
ieee
ISSN
1536-1241
Type
jour
DOI
10.1109/TNB.2004.842471
Filename
1402416
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