A new method for analysis of atrial activation during chronic atrial fibrillation in man

To further clarify the mechanisms maintaining chronic atrial fibrillation (CAF), a method identifying preferable activation patterns of the atria during fibrillation, by time averaging of multiple discrete excitation vectors, was developed. Repeated recordings, each of 56 atrial bipolar electrograms simultaneously acquired during 8 s, were made at multiple sites in the right atrial free wall and the left atrial appendage in 16 patients with CAF using a 2.17×3.54 cm electrode array. The local activation times (LAT´s) in each recording were estimated as the median activation time at the respective measurement point. By calculating the time difference between the LAT´s at adjacent measurement points in two spatial dimensions, a direction vector was created for each activation wave passing each set of measurement points, a total of 42 sets. By time averaging of the individual direction vectors (typically n=55) at each set of measurement points, preferable activation patterns were determined. Three types of activation patterns were found: 1) inconsistent activation (n=5), 2) consistent activation with preferential propagation directions (n=7) and 3) consistent activation with impulses originating from a localizable site within the recording area (n=4). All activation patterns were reproducible and the two latter patterns were proven significant using statistical tests. It is concluded that this new method is useful in further clarification of the mechanisms involved in the maintenance of atrial fibrillation.