Title :
Nanostructured Metal-Enhanced Raman Spectroscopy for DNA Base Detection
Author :
Zhu, Zhiqian ; Zhan, Li ; Hou, Cailing ; Wang, Zhimin
Author_Institution :
Dept. of Phys., Shanghai Jiao Tong Univ., Shanghai, China
Abstract :
Periodic arrays of subwavelength apertures on Ag film are used as the substrates for nanohole-enhanced Raman spectroscopy. This study presents a rectangular bull´s eye structure in an array. We demonstrate the quantitative features of the pattern by the finite-difference time-domain method. This structure is used to enhance the Raman spectroscopy of four DNA bases without labeling. The enhancement factor is up to 106. A 1.5-fold enhancement against the circular pattern experimentally confirms the role of sharp corners. This structure may be used in nucleotide identification and DNA sequencing.
Keywords :
DNA; Raman spectra; arrays; finite difference time-domain analysis; metallic thin films; molecular biophysics; nanobiotechnology; nanostructured materials; silver; Ag; DNA base detection; DNA sequencing; circular pattern; finite-difference time-domain method; fold enhancement; nanohole-enhanced Raman spectroscopy; nanostructured metal-enhanced Raman Spectroscopy; nucleotide identification; rectangular bulls eye structure; silver films; subwavelength aperture periodic arrays; Apertures; DNA; Films; Metals; Nanobioscience; Raman scattering; Substrates; DNA base detection; Raman spectroscopy; Subwavelength structure; sensors;
Journal_Title :
Photonics Journal, IEEE
DOI :
10.1109/JPHOT.2012.2208945
