Title :
Three-dimensional reconstruction of in vivo blood vessels in human skin using phase-resolved optical Doppler tomography
Author :
Zhao, Yonghua ; Brecke, Kjell Morten ; Ren, Hongwu ; Ding, Zhihua ; Nelson, J. Stuart ; Chen, Zhongping
Author_Institution :
Center for Biophys. Eng., California Univ., Irvine, CA, USA
Abstract :
Phase-resolved optical Doppler tomography (ODT) has very high sensitivity while maintaining a fast axial scanning rate, making it possible to reconstruct blood flow in three dimensions. Here we demonstrate an ODT system that employed novel signal-processing techniques to remove aliasing effects and artifacts caused by lateral scanning and target movement. The results show that these techniques not only simplified ODT, but also improved lateral scanning speed. Using these signal-processing techniques, three-dimensional images of in vivo blood vessels in human skin were then reconstructed
Keywords :
Doppler shift; Hilbert transforms; bio-optics; blood flow measurement; blood vessels; flow visualisation; image reconstruction; light interferometry; medical image processing; optical tomography; skin; 3D reconstruction; Doppler image processing; Hilbert transform; aliasing effects; artifacts; fast axial scanning rate; fringe phase difference; high sensitivity; human skin; in vivo blood vessels; low-coherence Michelson interferometry; optical coherence tomography; phase-resolved optical Doppler tomography; signal-processing techniques; target movement; Biomedical optical imaging; Blood flow; Blood vessels; Humans; Image reconstruction; In vivo; Optical imaging; Optical sensors; Skin; Tomography;
Journal_Title :
Selected Topics in Quantum Electronics, IEEE Journal of
DOI :
10.1109/2944.983296
