Title :
Optical Doppler tomography
Author :
Chen, Zhongping ; Zhao, Yonghua ; Srinivas, Shyam M. ; Nelson, Stuart J. ; Prakash, Neal ; Frostig, Ron D.
Author_Institution :
Beckman Laser Inst., California Univ., Irvine, CA, USA
Abstract :
Optical Doppler tomography (ODT) is an imaging modality that takes advantage of the short coherence length of a broad-band light sources to perform micrometer-scale, cross-sectional imaging of tissue structure and blood flow dynamics simultaneously. The authors review in this paper the principal of ODT and its applications. Results from in vitro and in vivo model studies demonstrated that ODT can map the blood flow velocity profile with high spatial resolution in scattering medium. ODT detection mechanisms are illustrated using Monte Carlo simulations. The application of ODT to image brain hemodynamics is demonstrated. Finally, the authors discuss the limitations of the current technology and application of a phase resolved technique to improve image speed and quality
Keywords :
Doppler measurement; Monte Carlo methods; biomedical imaging; blood flow measurement; brain; image resolution; light coherence; optical tomography; blood flow dynamics; blood flow velocity profile mapping; broad-band light sources; image quality; image speed; in vitro model studies; in vivo model studies; micrometer-scale cross-sectional imaging; optical Doppler tomography; phase resolved technique; short coherence length; tissue structure; Blood flow; Coherence; High-resolution imaging; In vitro; In vivo; Light sources; Optical imaging; Optical scattering; Spatial resolution; Tomography;
Journal_Title :
Selected Topics in Quantum Electronics, IEEE Journal of
DOI :
10.1109/2944.796340
