Title :
Macroporous/mesoporous bioglasses doped with Ag/TiO2 for dual drug action property and bone repair
Author :
Jiang, Pingping ; Qu, Fengyu ; Lin, Huiming ; Wu, Xiaojie ; Xing, R. ; Zhang, Juyong
Author_Institution :
Key Lab. of Semicond. Nanocomposite Mater., Harbin Normal Univ., Harbin, China
fDate :
9/1/2012 12:00:00 AM
Abstract :
A series of macroporous-mesoporous bioglasses (MMBGs) doped with Ag, TiO2 and Ag/TiO2 have been successfully prepared using the nature plants as the macroporous templates and P123 as the mesoporous one. The dual drug action (antifungus and anti-inflammatory) and bone regeneration systems have been obtained by Ibuprofen (Ibu) loaded. Meanwhile, the antifungus as well as drug control release profiles of these materials have been investigated. Compared with pure MMBGs, MMBGs-Ag, MMBGs-TiO2 and MMBGs-Ag/TiO2 showed much higher antimicrobial efficiency, faster hydroxyapatite-forming ability and better drug sustained release performance. The multifunctional hierarchical porous bioglasses materials may have potential applications in bone tissue engineering.
Keywords :
antibacterial activity; biomedical materials; bone; drugs; glass; mesoporous materials; polymer blends; silver; tissue engineering; titanium compounds; Ibuprofen; P123; SiO2:Ag; SiO2:Ag,TiO2; SiO2:TiO2; antifungus profiles; antimicrobial efficiency; bone regeneration systems; bone repair; bone tissue engineering; drug control release profiles; dual drug action property; hydroxyapatite-forming ability; macroporous templates; macroporous-mesoporous bioglasses; multifunctional hierarchical porous bioglass materials; nature plants;
Journal_Title :
Nanobiotechnology, IET
DOI :
10.1049/iet-nbt.2011.0058
