Title :
Tryptophan Fluorescence of Cells and Tissue in Esophageal Carcinoma
Author :
Banerjee, Bhaskar ; Graves, Logan R. ; Utzinger, Urs
Author_Institution :
Dept. of Gastroenterology, Univ. of Arizona, Tucson, AZ, USA
Abstract :
Cancer is a cellular process. The emission spectrum of tryptophan, which produces the strongest fluorescence in cells, was investigated in cells and tissues of a normal and malignant esophagus. Estimated fluorescence intensity per cell was about three times greater in cancerous cells than in normal cells. The fluorescence was also greater in cancerous tissue but the difference was attenuated, probably because of absorption and scattering. Cellular fluorescence from tryptophan may be useful for the detection of cancer in esophageal cells and tissues.
Keywords :
biological tissues; cancer; cellular biophysics; fluorescence; organic compounds; cancer detection; cancerous cells; cancerous tissue; cellular fluorescence; cellular process; emission spectrum; esophageal carcinoma; esophageal cells; esophageal tissues; fluorescence intensity; malignant esophagus; tryptophan fluorescence; Absorption; Biomedical optical imaging; Cancer; Esophagus; Fluorescence; Suspensions; Tumors; Autofluorescence; cancer; tryptophan;
Journal_Title :
Sensors Journal, IEEE
DOI :
10.1109/JSEN.2012.2212791
