Title :
Data-based core genes screening for Hepatocellular Carcinoma
Author :
Jinyu Hu ; Zhiwei Gao
Author_Institution :
Dept. of Biostat. & Comput. Biol., Univ. of Rochester, Rochester, NY, USA
Abstract :
In terms of the concepts of gene force and gene community network, a novel multi-layer filter is proposed to screen the core genes. Applying the present algorithm to liver cancer microarray data with 3964 genes, the three core genes, composed of iron-related gene HAMP, metal-related metallothionein genes, and tumor proliferation-related GPC3 gene are screened. Based on these core genes, the formation and development mechanism of the HCC and the relationship between the HCC and trace metals, such as copper, iron and zinc, are analyzed and revealed.
Keywords :
cancer; cellular biophysics; copper compounds; filtering theory; genetic algorithms; genetics; iron compounds; liver; medical diagnostic computing; molecular biophysics; proteins; zinc compounds; HCC development mechanism; HCC formation; data-based core genes screening; gene community network; gene force; hepatocellular carcinoma; iron-related gene HAMP; liver cancer microarray data algorithm; metal-related metallothionein genes; multilayer filter; trace metals; tumor proliferation-related GPC3 gene; Cancer; Copper; Correlation; Filtering algorithms; Iron; Liver; Zinc; core genes; data-based analysis; gene community network; hepatocellular carcinoma;
Conference_Titel :
Industrial Electronics and Applications (ICIEA), 2014 IEEE 9th Conference on
Conference_Location :
Hangzhou
Print_ISBN :
978-1-4799-4316-6
DOI :
10.1109/ICIEA.2014.6931330
