Title :
Surface plasmon resonance imaging for biosensing
Author :
Paul, Sudipta ; Vadgama, Pankaj ; Ray, A.K.
Author_Institution :
Sch. of Eng. & Mater. Sci., Queen Mary, Univ. of London, London, UK
fDate :
9/1/2009 12:00:00 AM
Abstract :
Surface plasmon resonance imaging (SPRI) is a useful tool for the study of surface biomolecular interactions allowing for label-free detection and elegant instrumentation. SPRI imaging system is described in this review with an emphasis on recent applications with examples of different biological interactions and high throughput analysis. Signal amplification in SPRI using nanoparticle and waveguide-based optical coupling is introduced. Finally the detection sensitivity of the SPRI system is examined in terms of other competitive methods.
Keywords :
bio-optics; biological techniques; biosensors; molecular biophysics; nanoparticles; nanotechnology; surface plasmon resonance; SPRI signal amplification; biosensor; detection sensitivity; label-free detection; nanoparticle-based optical coupling; surface biomolecular interaction; surface plasmon resonance imaging; waveguide-based optical coupling;
Journal_Title :
Nanobiotechnology, IET
DOI :
10.1049/iet-nbt.2008.0012
