• DocumentCode
    1291421
  • Title

    Ultrasensitive analysis with the crossed-beam thermal lens

  • Author

    Nolan, Thomas G. ; Dovichi, Norman J.

  • Author_Institution
    Dept. of Chem., Wyoming Univ., Laramie, WY, USA
  • Volume
    2
  • Issue
    1
  • fYear
    1986
  • Firstpage
    54
  • Lastpage
    56
  • Abstract
    The crossed-beam thermal lens is a two-beam laser technique that produces a high-spatial resolution measurement of weak optical absorbance. The technique has been used for scanning microscope, nonintrusive flow measurements, and liquid chromatographic detection. The authors report the detection of 120 analyte molecules within a 2×10-10 cm3 volume of liquid. The possibility of detecting and counting single antibodies is considered.
  • Keywords
    biological techniques and instruments; measurement by laser beam; spectrochemical analysis; thermo-optical effects; analyte molecules; antibody counting; crossed-beam thermal lens; high-spatial resolution measurement; liquid chromatographic detection; molecular detection; nonintrusive flow; photothermal refraction; scanning microscope; two-beam laser technique; ultrasensitive analysis; weak optical absorbance; Chemical lasers; Laser beams; Laser excitation; Lenses; Measurement by laser beam; Pump lasers; Thermal lensing;
  • fLanguage
    English
  • Journal_Title
    Circuits and Devices Magazine, IEEE
  • Publisher
    ieee
  • ISSN
    8755-3996
  • Type

    jour

  • DOI
    10.1109/MCD.1986.6311772
  • Filename
    6311772
    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=49&DC=1291421