MEMS-based silicon ultrasonic twin-nozzle nebulizer for inhalation drug delivery

Author

Mao, R.W. ; Lin, S.K. ; Tsai, Shih Chang ; Brenner, Markus ; Mahon, S. ; Boss, G. ; Smaldone, G. ; Tsai, C.S.

Author_Institution

Dept. of Elec. Eng. & Comp. Sci., Univ. of California, Irvine, Irvine, CA, USA

fYear

2014

fDate

3-6 Sept. 2014

Firstpage

742

Lastpage

744

Abstract

A versatile silicon-based ultrasonic nebulizer that utilizes a twin-nozzle of multiple Fourier horns at 1-2 MHz drive frequencies has been realized to perform simultaneous aerosolization of cobinamide and magnesium thiosulfate drug solutions. The drive frequency of the individual nozzle for a desirable aerosol diameter was individually designed. Using the 2.0 MHz 4-Fourier horn twin-nozzle aerosols of the two drug solutions with mass median diameter (MMD) of 3.0±0.1μm and geometrical standard deviation (GSD) of 1.18±0.02 and total flow rate up to 400μL/min were produced.

Keywords

aerosols; bioMEMS; drug delivery systems; nozzles; pneumodynamics; ultrasonic therapy; MEMS-based silicon ultrasonic twin-nozzle nebulizer; aerosolization; cobinamide; desirable aerosol diameter; drive frequency; geometrical standard deviation; inhalation drug delivery; magnesium thiosulfate drug solutions; mass median diameter; multiple Fourier horns; total flow rate; Acoustics; Aerosols; Drugs; Face; Liquids; Magnesium; Resonant frequency; Inhalation Drug Delivery; MEMS; Medicinal Aerosol Mixing; Multiple Fourier-horn Nozzle; Twin-Nozzle Ultrasonic Nebulizer;

fLanguage

English

Publisher

ieee

Conference_Titel

Ultrasonics Symposium (IUS), 2014 IEEE International

Conference_Location

Chicago, IL

Type

conf

DOI

10.1109/ULTSYM.2014.0183

Filename

6932042