Title :
Effects of mechanical stress/strain and estrogen on cancellous bone structure predicted by fuzzy decision
Author :
Luo, Zong-Ping ; Zhang, Lin ; Turner, Russell T. ; An, Kai-Nan
Author_Institution :
Orthopedic Biomech. Lab., Mayo Clinic, Rochester, MN, USA
fDate :
3/1/2000 12:00:00 AM
Abstract :
A theoretical model was developed on the basis of fuzzy decision to predict cancellous bone structure following changes In mechanical stress/strain and estrogen. The model was validated experimentally by simulation of the normal structure of a rat distal femur, and further used to predict the structural alterations following ovarian hormone deficiency. The results show that net bone resorption after ovariectomy occurs in the metaphysis at locations where trabecula were subjected to the lowest mechanical stress/strain. These findings, consistent with experimental results, suggest that estrogen deficiency increase the mechanostat set point at which bone cells perceive mechanical stress/strain. Additionally, the results show that changes in bone architecture which are due to alterations in bone remodeling can be simulated by fuzzy decision without precise mathematical description, and multiple factors can also be readily incorporated into the model.
Keywords :
biochemistry; biomechanics; bone; fuzzy logic; organic compounds; physiological models; bone architecture changes; cancellous bone structure; estrogen effects; fuzzy decision; mechanical stress/strain effects; mechanostat set point; metaphysis; net bone resorption; ovarian hormone deficiency; ovariectomy; precise mathematical description; rat distal femur; structural alterations; trabecula; Biochemistry; Biological system modeling; Cancellous bone; Capacitive sensors; Immune system; Laboratories; Orthopedic surgery; Predictive models; Strain measurement; Stress; Animals; Bone Density; Bone Resorption; Bone and Bones; Epiphyses; Estrogens; Female; Femur; Fuzzy Logic; Models, Biological; Ovariectomy; Rats; Rats, Sprague-Dawley; Stress, Mechanical;
Journal_Title :
Biomedical Engineering, IEEE Transactions on