Bispectrum analysis of focal ischemic cerebral EEG signal using third-order recursion method

In this paper, a model for Sprague-Dawley (SD) rat focal ischemic cerebral injury is presented. Based on this experimental model, the electroencephalogram (EEG) from the ischemic region and from a normal region are collected during the first 30 min of ischemia. The EEG bispectrum analysis is carefully investigated by using the third-order recursion method. The authors found that some characteristics of the bispectrum are very sensitive to focal ischemic cerebral injury. The maximum magnitude and the weighted center of EEG bispectrum (WCOB) change according to the extent and the place of the injury region. The bispectrum analysis results have been verified by the heat shock protein (HSP) test. The study indicates that the EEG bispectrum analysis may be useful to distinguish the ischemic region from the normal one and to estimate the ischemic extent.