Title :
A box coil for the stimulation of biological tissue and cells in vitro and in vivo by pulsed magnetic fields
Author :
Battocletti, Joseph H. ; Macias, Melissa Y. ; Pintar, Frank A. ; Maiman, Dennis J. ; Sutton, Carl H.
Author_Institution :
Dept. of Neurosurg., Med. Coll. of Wisconsin, Milwaukee, WI, USA
fDate :
3/1/2000 12:00:00 AM
Abstract :
An alternative coil system to the Helmholtz coil-pair is described for the stimulation of biological tissue and cells: a relatively large box coil made of copper or aluminum sheet stock. The design is based on the principal determinant of the induced electric field, namely, the magnetic vector potential (A), in the equation, E=-∂A/∂t-∇V. The second term in the equation is needed when boundaries of the conducting medium are in close proximity to the region of interest, such as in a culture dish. An electric surface charge builds up on the boundaries to generate an electric field which cancels -∂A/∂t at the surface. The effectiveness of the new coil is demonstrated in a study of the outgrowth enhancement of axons from rat embryonic dorsal root ganglia.
Keywords :
biological effects of fields; biological techniques; biological tissues; biomagnetism; cellular effects of radiation; coils; magnetic field effects; neurophysiology; Al; Cu; Helmholtz coil-pair; aluminum sheet; axons; biological tissue stimulation; biophysical research instrumentation; box coil; conducting medium boundaries; copper sheet; culture dish; electric surface charge; induced electric field; magnetic vector potential; outgrowth enhancement; pulsed magnetic fields; rat embryonic dorsal root ganglia; Aluminum; Biological tissues; Cells (biology); Coils; Copper; Equations; In vitro; In vivo; Magnetic fields; Nerve fibers; Animals; Cells, Cultured; Electric Stimulation; Electromagnetic Fields; Equipment Design; Ganglia, Spinal; Nerve Regeneration; Neurites; Rats; Rats, Sprague-Dawley;
Journal_Title :
Biomedical Engineering, IEEE Transactions on
