Title :
In-beam PET imaging for the control of heavy-ion tumour therapy
Author :
Pawelke, J. ; Enghardt, W. ; Haberer, Th ; Hasch, B.G. ; Hinz, R. ; Krämer, M. ; Lauckner, K. ; Sobiella, M.
Author_Institution :
Inst. fur Kern- und Hadronenphys., Forschungszentrum Rossendorf, Dresden, Germany
fDate :
8/1/1997 12:00:00 AM
Abstract :
A method for the in-situ control of the heavy-ion tumour therapy by means of positron emission tomography is introduced. This method is founded on the measurement of the dynamic spatial distributions of β+-emitters generated by nuclear fragmentation during the irradiation and their relation to the dose. In order to study this relationship and to derive the dose distribution from the measured β+-activity distribution, a framework of model calculations is used. Results of phantom experiments with 12C ion beams are presented, demonstrating good agreement between experiment and calculation as well as the possibilities and limits of the PET-technique for treatment plan verification and beam monitoring
Keywords :
biocontrol; dosimetry; ion beam applications; positron emission tomography; radiation therapy; β+-emitters; 12C ion beams; C; beam monitoring; dose distribution; dynamic spatial distribution; heavy-ion tumour therapy control; in-beam PET imaging; in-situ control method; model calculations framework; nuclear fragmentation; phantom experiments; treatment plan verification; Biomedical applications of radiation; Ion beams; Magnetic variables control; Medical treatment; Monitoring; Nuclear power generation; Particle beams; Positron emission tomography; Shape; Tumors;
Journal_Title :
Nuclear Science, IEEE Transactions on
