Title :
In Silico Search of DNA Drugs Targeting Oncogenes
Author :
Papadakis, George ; Gizeli, Electra
Author_Institution :
Dept. of Biol., Univ. of Crete, Heraklion, Greece
Abstract :
Triplex forming oligonucleotides (TFOs) represent a class of drug candidates for antigene therapy. Based on strict criteria, we investigated the potential of 25 known oncogenes to be regulated by TFOs in the mRNA synthesis level and we report specific target sequences found in seven of these genes.
Keywords :
DNA; RNA; cancer; drugs; genetics; molecular biophysics; DNA drugs; antigene therapy; mRNA synthesis level; oncogenes; target sequences; triplex forming oligonucleotides; Bioinformatics; Cancer; DNA; Encoding; Genomics; Stability analysis; Antigene therapy; oncogenes; transcription inhibition; triplex forming oligos; Animals; Antineoplastic Agents; Base Sequence; Computer Simulation; DNA; Drug Discovery; Gene Targeting; Humans; Mice; Molecular Sequence Data; Molecular Targeted Therapy; Nucleic Acid Conformation; Oligonucleotides; Oncogenes; RNA, Messenger; Sequence Analysis, DNA; Transcription, Genetic;
Journal_Title :
Computational Biology and Bioinformatics, IEEE/ACM Transactions on
DOI :
10.1109/TCBB.2012.127
