DocumentCode
1313471
Title
Actively shielded 8 tesla magnet for FT-ICR mass spectrometry
Author
Devernoe, A. ; Parizh, M. ; Rutman, G. ; Kagan, A. ; King, M. ; Ciancetta, G. ; Wilcox, R. ; Winger, B.
Author_Institution
Intermagnetics Gen. Corp., Latham, NY, USA
Volume
10
Issue
1
fYear
2000
fDate
3/1/2000 12:00:00 AM
Firstpage
767
Lastpage
770
Abstract
Intermagnetics successfully delivered an 8 tesla magnet for Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (FT-ICR). This high field magnet is used by Lilly Research Laboratories for routine high-resolution and exact mass analysis of higher molecular weight biopharmaceutical and biotechnology products such as proteins, DNA, etc. The system includes a NbTi magnet with high homogeneity and persistence, and a cryocooler refrigerated cryostat with a low He boil off and a long refill interval. The magnet system incorporates many of the user-friendly features of Intermagnetics´ line of Magnet Resonance Imaging (MRI) magnets including a compact self-shielded configuration, high uniformity, nitrogen-free cryogenic technology, cold-shippable for fast setup on site, and other features. The 100 cm long magnet has a 152 mm diameter horizontal room temperature bore. The achieved uniformity is better than 6 ppm peak-to-peak in a 50 mm diameter, 50 mm long cylinder. The guaranteed magnet persistence is better than 50 ppb/hour. The 5 gauss line is located 1.4 m radially and 2.4 m axially from the magnet iso-center, resulting in a stray field that is even closer to the cryostat than in lower field unshielded FT-ICR magnets. Liquid helium refill interval is 6 months or longer. Due to the reduced stray field, compactness and relatively lightweight design, this magnet may be used to replace lower field, unshielded magnets in mass spectrometry facilities.
Keywords
Fourier transform spectroscopy; magnetic shielding; mass spectroscopic chemical analysis; superconducting magnets; 8 T; FT-ICR mass spectrometry; NbTi; active shielding; biopharmaceutical product; biotechnology product; cryocooler; high field magnet; stray field; superconducting magnet; Biotechnology; Cyclotrons; Fourier transforms; Laboratories; Magnetic analysis; Magnetic shielding; Mass spectroscopy; Proteins; Resonance;
fLanguage
English
Journal_Title
Applied Superconductivity, IEEE Transactions on
Publisher
ieee
ISSN
1051-8223
Type
jour
DOI
10.1109/77.828344
Filename
828344
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