Adaptive Control of Excitation Coil Arrays for Targeted Magnetic Nanoparticle Reconstruction Using Magnetorelaxometry

Magnetic nanoparticles are increasingly applied in biomedical diagnostic and therapeutic modalities. Due to their superparamagnetic properties it is possible to sense and manipulate these particles. In order to obtain the most effective operation of biomedical modalities and to achieve the highest comfort for the patients, it is essential to quantitatively assess the spatial distribution of the magnetic nanoparticles. From the various techniques available, magnetorelaxometry has a high potential for the spatial recovery of the concentration of magnetic nanoparticles. Through the correct interpretation of the measurements it is possible to quantitatively determine the spatial distribution of the particles concentration. We investigate an adaptive control technique that activates excitation coil arrays for targeted magnetic nanoparticle reconstruction.