A mathematical model of overall cerebral blood flow regulation in the rat

Author

Ursino, Mauro

Author_Institution

Dept. of Electron., Comput. Sci., & Syst., Bologna, Italy

Volume

38

Issue

8

fYear

1991

Firstpage

795

Lastpage

807

Abstract

A mathematical model of the cerebrovascular regulatory system in the rat is presented. The model, a generalization of a previous one, includes the reactivity of proximal segments of the cerebrovascular bed and the neurogenic and myogenic feedback regulatory mechanisms besides the action of chemical regulatory factors. The model is used to analyze the interaction of mechanisms regulating cerebral blood flow in several conditions of physiological importance. A comparison of simulation results with recent experimental data shows that the model is able to produce 60-70% of the experimental regulatory capacity of the cerebrovascular bed. However, some relevant discrepancies still exist between the model and the experimental results, especially as regards the dilatory capacity of small cerebral arterioles.

Keywords

brain models; haemodynamics; cerebral arterioles dilatory capacity; cerebral blood flow regulation; cerebrovascular bed; chemical regulatory factors; mathematical model; myogenic feedback regulatory mechanisms; neurogenic mechanisms; rat; Arteries; Blood flow; Blood pressure; Chemicals; Control system synthesis; Delay effects; Helium; In vivo; Mathematical model; Neurofeedback; Animals; Biomechanics; Brain Ischemia; Cerebrovascular Circulation; Computer Simulation; Feedback; Homeostasis; Models, Cardiovascular; Rats; Reference Values; Vascular Resistance; Vasodilation;

fLanguage

English

Journal_Title

Biomedical Engineering, IEEE Transactions on

Publisher

ieee

ISSN

0018-9294

Type

jour

DOI

10.1109/10.83592

Filename

83592